BEMÆRK: Ansøgningsfristen er overskredet
We are offering a PhD fellowship in MS-based proteomics commencing 1 November 2023.
Our group and research
The Olsen Group address unsolved questions in cell signaling. The group aims to characterize how signaling networks regulate cellular responses differentially when mediated by phosphorylation and other modifications.
The major scientific focus area for the Olsen Group is quantitative, high-resolution mass spectrometry-based proteomics with specific emphasis on mass spectrometric technology developments and biological applications in cell signalling and cancer.
Project description
As part of an international collaborative project, the PhD student will unravel the cellular signaling events downstream of the kinase inhibitor regorafenib in Glioblastoma (GBM) to identify its protein targets. Delineating the molecular mechanisms of regorafenib resistance will present drug targets to overcome resistance to this multi-kinase inhibitor, and eventually further improve patient survival by rational drug combinations. To achieve this ambitious goal, state-of-the-art mass spectrometry (MS)-based proteomics will be exploited, which allows to comprehensively analyze the entire protein complement of a cell, including post-translational modifications (PTMs) and their interaction with small molecules including kinase inhibitor drugs. Quantitative proteomics, phosphoproteomics and thermal proteome profiling will be employed to globally profile the cellular regorafenib response. Using this systems level strategy, the PhD student will help identify the molecular traits of both intrinsic and acquired resistance to regorafenib in patient-derived GBM cells.
Principal supervisor is Professor Jesper Velgaard Olsen, jesper.olsen@cpr.ku.dk.
Start: 1 November 2023
Duration: 3 years as a PhD student
Job description
Your key tasks as a PhD student at SUND are:
- Carrying through an independent research project under supervision.
- Completing PhD courses or other equivalent education corresponding to approximately 30 ECTS points.
- Participating in active research environments including a stay at another research team.
- Obtaining experience with teaching or other types of dissemination related to your PhD project
- Teaching and disseminating your knowledge.
- Writing a PhD thesis on the grounds of your project
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project, e.g. master degree in medical biology, biochemistry, chemical biology, or cell biology. Please note that your master’s degree must be equivalent to a Danish master’s degree (two years).
Other important criteria are:
- The grade point average achieved
- Professional qualifications relevant to the PhD project
- Previous publications in the field
- Relevant work experience in mass spectrometry and proteomics of cancer cells.
- Other professional activities
- A curious mind-set with a strong interest in cell signalling and cancer.
- Language skills
The place of employment is at Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories.
Terms of employment
The average weekly working hours are 37 hours per week.
The position is a fixed-term position limited to a period of 3 years.
The employment is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.
The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree.
Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Taxation and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary starts at approximately 28,800 DKK/Roughly 3,800 EUR (April 2023 level) plus pension.
Questions
For specific information about the PhD fellowship, please contact the principal supervisor.
General information about PhD studies at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/.
Application procedure
Your application must be submitted by clicking ‘Apply now’ below. The application must include the following documents in PDF format:
1. Motivated letter of application (max. one page)
2. CV incl. education, experience, language skills and other skills relevant for the position
3. Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted. As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science
4. Publication list (if possible)
Application deadline: 30 August 2023, 23.59pm CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You find information about the recruitment process at: http://employment.ku.dk/faculty/recruitment-process/
The applicants will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
København Kommune
-Virksomheden tilbyder:
-Arbejdsgiver:
KU - SUND - PANUM KBH N, Blegdamsvej 3B, 2200 København N
-Ansøgning:
Ansøgningsfrist: 30-08-2023; - ansøgningsfristen er overskredet
Ved skriftlig henvendelse: https://candidate.hr-manager.net/ApplicationInit.aspx?cid=1307&ProjectId=159957&DepartmentId=19221&MediaId=4632&SkipAdvertisement=true
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/5892142
